Long-term epigenetic changes in offspring mice exposed to alcohol during gestation and lactation.

Lídia CantacorpsSilvia Alfonso-LoechesConsuelo GuerriOlga Valverde

Published in: Journal of psychopharmacology (Oxford, England) (2019)

In conclusion, our results reveal that maternal binge-like alcohol consumption induces persistent epigenetic modifications, effects that might be associated with the long-term cognitive and behavioural impairments observed in foetal alcohol spectrum disorder models.

Keyphrases

alcohol consumption
spectrum disorder
dna methylation
gene expression
gestational age
genome wide
high fat diet
preterm infants
single cell
dairy cows
high fat diet induced
pregnant women
pregnancy outcomes
body mass index
weight loss