Amount of Pannexin 1 in Smooth Muscle Cells Regulates Sympathetic Nerve-Induced Vasoconstriction.
Luke S DunawayMarie BillaudEdgar MacalMiranda E GoodChristopher B MedinaUlrike LorenzKodi RavichandranC Michael HartBrant E IsaksonPublished in: Hypertension (Dallas, Tex. : 1979) (2022)
These data suggest Panx1 in SMCs could regulate the extent of sympathetic nerve constriction and blood pressure. The results also show the feasibility humanized Panx1-mouse models to test pharmacological candidates.