Targeting G-quadruplex motifs interferes with differentiation of adipose-derived mesenchymal stem cells.

Maria Rosaria AmbrosioTeresa MigliaccioFabiana NapolitanoSarah Di SommaGiovanni ManeliJussara AmatoBruno PaganoAntonio RandazzoGiuseppe PortellaPietro FormisanoAnna Maria Malfitano

Published in: Stem cell research & therapy (2023)

Our data highlight a new role of G4 motifs as genomic structural elements related to human ASC differentiation into mature adipocytes, with potential implications in physio-pathological processes.

Keyphrases

adipose tissue
endothelial cells
electronic health record
induced pluripotent stem cells
cancer therapy
insulin resistance
copy number
dna methylation
machine learning
metabolic syndrome
type diabetes
drug delivery