High-frequency electrical stimulation attenuates neuronal release of inflammatory mediators and ameliorates neuropathic pain.
Huan YangTimir Datta-ChadhuriSam J GeorgeBilal HaiderJason WongTyler D HeplerUlf AnderssonMichael BrinesKevin J TraceySangeeta S ChavanPublished in: Bioelectronic medicine (2022)
These studies reveal a previously unidentified mechanism for the pain-modulating effect of HFES in the setting of acute and chronic nerve injury. The results support the mechanistic insight that HFES may reset sensory neurons into a less pro-inflammatory state via inhibiting the release of neuroinflammatory mediators resulting in reduced inflammation and pain.
Keyphrases
- neuropathic pain
- high frequency
- spinal cord
- spinal cord injury
- transcranial magnetic stimulation
- oxidative stress
- signaling pathway
- chronic pain
- liver failure
- drug induced
- pain management
- mouse model
- intensive care unit
- aortic dissection
- brain injury
- cerebral ischemia
- blood brain barrier
- mechanical ventilation
- dna methylation