Functions of resolvin D1-ALX/FPR2 receptor interaction in the hemoglobin-induced microglial inflammatory response and neuronal injury.
Guang-Jie LiuTao TaoHan WangYan ZhouXuan GaoYong-Yue GaoChun-Hua HangWei LiPublished in: Journal of neuroinflammation (2020)
The results of the present study indicated that the RvD1-ALX/FPR2 interaction could potentially play dual roles in the CNS, as inhibiting Hb promoted microglial pro-inflammatory polarization and ameliorating Hb induced neuronal oxidant damage and death. These results shed light on a good therapeutic target (ALX/FPR2) and a potential effective drug (RvD1) for the treatment of SAH and other inflammation-associated brain diseases.
Keyphrases
- inflammatory response
- lipopolysaccharide induced
- oxidative stress
- diabetic rats
- high glucose
- lps induced
- drug induced
- cerebral ischemia
- neuropathic pain
- signaling pathway
- emergency department
- multiple sclerosis
- risk assessment
- immune response
- human health
- spinal cord injury
- climate change
- binding protein
- adverse drug
- replacement therapy
- red blood cell