Homogeneous nanodiscs of native membranes formed by stilbene-maleic-acid copolymers.
Mansoore EsmailiChanelle J BrownRustem ShaykhutdinovClaudia Acevedo-MorantesYong Liang WangHolger WilleRichard D GandourS Richard TurnerMichael OverduinPublished in: Nanoscale (2020)
Methylstilbene-alt-maleic acid copolymers spontaneously convert biological membranes into bilayer discs with ∼20 nm diameters. This readily functionalizable class of copolymers has the compositional homogeneity, hydrophobicity, dynamics, and charge that may help to achieve optimal structural resolution, membrane dissolution, stability, and broad utility.
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