Adipose tissue insulin resistance exacerbates liver inflammation and fibrosis in a diet-induced NASH model.

Yusei Hosokawa Tetsuya HosookaMakoto ImamoriKanji Yamaguchi Yoshito Itoh Wataru Ogawa

Published in: Hepatology communications (2023)

A-PDK1KO mice fed with the GAN diet, constitute a new mouse model for studies of the pathogenesis of NAFLD-NASH, especially that in lean individuals, as well as for the development of potential therapeutic strategies for this disease.

Keyphrases

insulin resistance
adipose tissue
high fat diet induced
mouse model
high fat diet
oxidative stress
polycystic ovary syndrome
metabolic syndrome
skeletal muscle
type diabetes
physical activity
weight loss
case control
bone mineral density
human health
glycemic control
postmenopausal women
light emitting
wild type