Deciphering the complex interplay between pancreatic cancer, diabetes mellitus subtypes and obesity/BMI through causal inference and mediation analyses.

Esther Molina-MontesClaudia CosciaPaulina Gómez-RubioAlba FernándezRianne BoeninkMarta RavaMirari MárquezXavier MoleroMatthias LöhrLinda SharpChristoph W MichalskiAntoni FarréJosé PereaMichael O'RorkeWilliam GreenhalfMar IglesiasAdonina TardónThomas M GressVictor M BarberáTatjana Crnogorac-JurcevicLuis Muñoz-BellvísJ Enrique Dominguez-MuñozHarald RenzJoaquim BalcellsEithne CostelloLucas IlzarbeJörg KleeffBo KongJosefina MoraDamian O'DriscollIgnasi PovesAldo ScarpaJingru YuManuel HidalgoRita T LawlorWeimin YeAlfredo CarratoFrancisco X RealNúria Malatsnull null

Published in: Gut (2020)

Findings of this study do not support a causal effect of LSDM on PC, but suggest that PC causes NODM. The interplay between obesity, PC and T2DM is complex.

Keyphrases

insulin resistance
weight gain
metabolic syndrome
weight loss
type diabetes
high fat diet induced
body mass index
glycemic control
adipose tissue
single cell
physical activity