Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer's disease.

Cécile TissotAndréa L BenedetJoseph TherriaultTharick A PascoalFiroza Z LussierParamita Saha-ChaudhuriMira ChamounMelissa SavardSulantha S MathotaarachchiGleb BezginYi-Ting WangJaime Fernandez AriasJuan Lantero RodriguezAnniina SnellmanNicholas J AshtonThomas K KarikariKaj BlennowHenrik ZetterbergEtienne De Villers-SidaniPhilippe HuotSerge GauthierPedro Rosa-Netonull null

Published in: Alzheimer's research & therapy (2021)

Higher levels of plasma pTau181 correlate with neurodegeneration and predict further brain atrophy in aging and Alzheimer's disease. Plasma pTau181 may be useful in predicting AD-related neurodegeneration, comparable to positron emission tomography or cerebrospinal fluid assessment with high specificity for AD neurodegeneration.

Keyphrases

positron emission tomography
computed tomography
cerebrospinal fluid
resting state
white matter
cognitive decline
pet ct
pet imaging
functional connectivity
cerebral ischemia
multiple sclerosis
clinical evaluation