Excess weight, polygenic risk score and findings of colorectal neoplasms at screening colonoscopy.
Ruojin FuXuechen ChenTobias NiedermaierTeresa L SeumMichael HoffmeisterHermann BrennerPublished in: The American journal of gastroenterology (2024)
Excess weight and polygenic risk are associated with increased risk of colorectal neoplasms in a multiplicative manner. Maintaining normal weight is estimated to have an equivalent effect as having 38 percentiles lower PRS.