Selective deletion of endothelial mineralocorticoid receptor protects from vascular dysfunction in sodium-restricted female mice.
Jessica L FaulknerEmily LluchSimone KennardGalina AntonovaIris Z JaffeEric J Belin de ChantemèlePublished in: Biology of sex differences (2020)
Collectively, these data indicate that female mice develop aldosterone-induced endothelial dysfunction via endothelial MR-mediated reductions in NO bioavailability. In addition, these data support a role for ECMR to promote vascular contractility in female mice in response to sodium restriction.