Unraveling the role of male reproductive tract and haemolymph in cantharidin-exuding Lydus trimaculatus and Mylabris variabilis (Coleoptera: Meloidae): a comparative transcriptomics approach.

Emiliano FratiniMarco SalveminiFabrizio LombardoMaurizio MuzziMarco MolfiniSilvia GisondiElia RomaVeronica D'EzioTiziana PersichiniTecla GasperiPaolo MariottiniAndrea Di GiulioMarco Alberto BolognaManuela CervelliEmiliano Mancini

Published in: BMC genomics (2021)

The de novo assembled transcriptomes of L. trimaculatus and M. variabilis here provided represent valuable genetic resources to further explore the mechanisms employed to cope with toxicity of CA in blister beetle tissues. These, if revealed, might help conceiving safe and effective drug-delivery approaches to enhance the use of CA in medicine.

Keyphrases

single cell
drug delivery
protein kinase
gene expression
oxidative stress
genome wide
cancer therapy
copy number
drug release