A New Role for Conivaptan in Ulcerative Colitis in Mice: Inhibiting Differentiation of CD4+T Cells into Th1 Cells.

Dandan DouYuge JiJunjie ZhengJingxin LiXiaolong ZhuShuhai TangHongjuan WangQin LiHaiyan Jing

Published in: Digestive diseases and sciences (2021)

For the first time, we report that conivaptan attenuated colitis by inhibiting the differentiation of CD4+ T cells into Th1 cells. Mechanistically, the anti-inflammatory role of conivaptan is independent of [Ca2+]i.

Keyphrases

induced apoptosis
ulcerative colitis
signaling pathway
cell cycle arrest
anti inflammatory
oxidative stress
cell proliferation
cell death
metabolic syndrome
insulin resistance