Noncanonical Form of ERAD Regulates Cardiac Hypertrophy.
Erik A BlackwoodLauren F MacDonnellDonna J ThueraufAlina S BilalVictoria B MurrayKenneth B MarguliesKenneth B MarguliesChristopher C GlembotskiPublished in: Circulation (2022)
ERAD-Out is a new preferentially favored noncanonical form of ERAD that mediates the degradation of SGK1 in cardiac myocytes, and in so doing is therefore an important determinant of how the heart responds to pathological stimuli, such as pressure overload.
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