Advanced Paternal Age and Sperm DNA Fragmentation: A Systematic Review.
Daniel C GonzalezJesse OryRuben Blachman-BraunSirpi NackeeranJordan C BestRanjith RamasamyPublished in: The world journal of men's health (2021)
Although there was no universal definition for APA, the present review suggests that older age is associated with increased DFI. In elderly men with normal semen parameters, further studies should be performed to assess the clinical implications of DFI, as a conventional semen analysis can often fail to detect an etiology for infertility.