Familial Aggregation of Childhood- and Adulthood-Onset Systemic Lupus Erythematosus.
Nailú Angélica SinicatoLuciana de OliveiraAlineTamires LapaMariana PostalKarinade Oliveira PeliçariLilian T L CostallatRoberto MariniVera Lúcia Gil-da-Silva-LopesTimothy B NiewoldSimone AppenzellerPublished in: Arthritis care & research (2020)
The greater decline in SLE recurrence rate by generation in childhood-onset SLE versus adult-onset SLE suggests a more polygenic and epistatic inheritance and suggests that adult-onset SLE may be characterized by fewer risk factors that are individually stronger. This finding suggests a higher genetic load in childhood-onset SLE versus adult-onset SLE and a difference in the genetic architecture of the disease based on age at onset.