Exophiarin, an isocoumarin from the fungus Exophiala sp. with antihyperglycemic activity.
Akash R GohilShivankar AgrawalVaishali BhattacharyaRahul LavhaleShilpa VerekarAbhijeet S KatePublished in: Natural product research (2019)
Chemical characterization of ethyl acetate extract of Exophiala sp. has afforded the isolation of three compounds including a new isocoumarin named exophiarin (1). Exophiala sp. was obtained from the soil containing dumped organic waste (litter). Initially, LC-UV-MS analysis of the extract of Exophiala sp. revealed the presence of a new compound having molecular weight 438 (1) and previously reported TPI-2 and TPI-5. The novelty was established using advanced database search comprising of biological source, molecular weight and UV profile. 1D, 2D NMR and HRMS data have been used for structure elucidation. Exophiarin with TPI-2 and TPI-5 have displayed moderate improvement in glucose uptake activity when tested in rat skeletal muscle cell line L6.
Keyphrases
- skeletal muscle
- oxidative stress
- mass spectrometry
- multiple sclerosis
- magnetic resonance
- anti inflammatory
- heavy metals
- emergency department
- ms ms
- type diabetes
- machine learning
- blood glucose
- adipose tissue
- blood pressure
- big data
- deep learning
- metabolic syndrome
- weight loss
- liquid chromatography
- sewage sludge
- cell wall