Lipofibroblasts form a sub-population of fibroblasts located in the mesenchymal alveolar stem cell niche. They show close proximity with alveolar epithelial type 2 cells and play a key role in alveolar development and lung homeostasis. Their role in various diseases such as acute respiratory distress syndrome, pulmonary fibrosis and emphysema is progressively better understood. Through the activation of signaling pathways such as PPARg lipofibroblasts may help to induce endogenous alveolar regeneration.
Keyphrases
- stem cells
- pulmonary fibrosis
- acute respiratory distress syndrome
- chronic obstructive pulmonary disease
- extracorporeal membrane oxygenation
- induced apoptosis
- signaling pathway
- mechanical ventilation
- pulmonary hypertension
- bone marrow
- idiopathic pulmonary fibrosis
- cell cycle arrest
- intensive care unit
- cell death
- pi k akt
- oxidative stress
- endoplasmic reticulum stress
- mesenchymal stem cells
- air pollution