Protein Tyrosine Phosphatase 1B Deficiency in Vascular Smooth Muscle Cells Promotes Perivascular Fibrosis following Arterial Injury.

Rajinikanth GogirajuSogol GachkarDavid VelmedenMagdalena L BochenekKonstantinos ZifkosAstrid HubertThomas MünzelStefan OffermannsKatrin Schäfer

Published in: Thrombosis and haemostasis (2022)

Chronic reduction of PTP1B in SMCs promotes dedifferentiation, perivascular fibrosis, and adverse remodeling following vascular injury by mechanisms involving an ERK1/2 phosphorylation-driven shift from SMAD2 to KLF4-regulated gene transcription.

Keyphrases

vascular smooth muscle cells
transcription factor
angiotensin ii
signaling pathway
epithelial mesenchymal transition
protein kinase
cell proliferation
transforming growth factor
genome wide
copy number
pi k akt
liver fibrosis
emergency department
amino acid
replacement therapy
binding protein
smoking cessation