Genome-Transcriptome-Functional Connectivity-Cognition Link Differentiates Schizophrenia From Bipolar Disorder.
Jiayu ChenZening FuJuan R BustilloNora I Perrone-BizzozeroDongdong LinJose CaniveGodfrey D PearlsonJulia M StephenAndrew R MayerSteven G PotkinTheo G M van ErpPeter KochunovL Elliot HongBhim M AdhikariOle A AndreassenIngrid AgartzLars Tjelta WestlyeJing SuiYuhui DuFabio MacciardiFaith M HanlonRex E JungJessica A TurnerJingyu LiuVince D CalhounPublished in: Schizophrenia bulletin (2022)
Collectively, these multiscale findings support the hypothesis that SZ-biased genetic risk, through transcriptome regulation, is linked to frontoparietal dysconnectivity, which in turn contributes to differential cognitive deficits in SZ-versus BD, suggesting that potential biomarkers for more precise patient stratification and treatment.