Yellow fever disease severity and endothelial dysfunction are associated with elevated serum levels of viral NS1 protein and syndecan-1.
Francielle T G de SousaColin M WarnesErika R ManuliArash NgLuiz G F A B D'Elia ZanellaYeh-Li HoSamhita BhatCamila M RomanoP Robert BeattyScott B BieringEsper G KallasEster Cerdeira SabinoEva HarrisPublished in: medRxiv : the preprint server for health sciences (2023)
and in mouse models. Further, we developed a YFV NS1-capture ELISA that serves as a proof-of-concept for low-cost NS1-based diagnosis/prognosis tools for YF. Together, our data shows that YFV NS1 and endothelial dysfunction are important components of YF pathogenesis.