Targeting cancer stem cell OXPHOS with tailored ruthenium complexes as a new anti-cancer strategy.
Sonia AlcaláLara VillarinoLaura Ruiz-CañasJosé R CouceiroMiguel Martínez-CalvoAdrián Palencia-CamposDiego NavarroPablo Cabezas-SainzIker Rodriguez-ArabaolazaAlfonso Cordero-BarrealLucia Trilla-FuertesJuan A RubioloSandra Batres-RamosMireia VallespinosCristina González-PáramosJéssica RodríguezAngelo Gámez-PozoJuan Ángel Fresno VaraSara Fra FernándezAmparo Benito BerlinchesNicolás Moreno-MataAna María Torres RedondoAlfredo CarratoPatrick C HermannLaura SánchezSusana TorrenteMiguel Ángel Fernández-MorenoJosé L MascareñasBruno SainzPublished in: Journal of experimental & clinical cancer research : CR (2024)
Overall, the coordination complex Ru1 represents not only an exciting new anti-cancer agent, but also a molecular tool to dissect the role of OXPHOS in CSCs. Results indicating that the compound is safe, non-toxic and highly effective in vivo are extremely exciting, and have allowed us to uncover unprecedented mechanistic possibilities to fight different cancer types based on targeting CSC OXPHOS.