Can Population Modelling Principles be Used to Identify Key PBPK Parameters for Paediatric Clearance Predictions? An Innovative Application of Optimal Design Theory.
Elisa A M CalvierThu Thuy NguyenTrevor N JohnsonAmin Rostami-HodjeganDick TibboelElke H J KrekelsCatherijne A J KnibbePublished in: Pharmaceutical research (2018)
The proposed framework can be applied to other PBPK parameters and facilitate the development of PBPK models.
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