Antimonene Quantum Dots: Synthesis and Application as Near-Infrared Photothermal Agents for Effective Cancer Therapy.
Wei TaoXiaoyuan JiXiaoding XuMohammad Ariful IslamZhongjun LiSi ChenPhei Er SawQizhen ZhangZameer BharwaniZilei GuoJin-Jun ShiOmid C FarokhzadPublished in: Angewandte Chemie (International ed. in English) (2017)
Photothermal therapy (PTT) has shown significant potential for cancer therapy. However, developing nanomaterials (NMs)-based photothermal agents (PTAs) with satisfactory photothermal conversion efficacy (PTCE) and biocompatibility remains a key challenge. Herein, a new generation of PTAs based on two-dimensional (2D) antimonene quantum dots (AMQDs) was developed by a novel liquid exfoliation method. Surface modification of AMQDs with polyethylene glycol (PEG) significantly enhanced both biocompatibility and stability in physiological medium. The PEG-coated AMQDs showed a PTCE of 45.5 %, which is higher than many other NMs-based PTAs such as graphene, Au, MoS2 , and black phosphorus (BP). The AMQDs-based PTAs also exhibited a unique feature of NIR-induced rapid degradability. Through both in vitro and in vivo studies, the PEG-coated AMQDs demonstrated notable NIR-induced tumor ablation ability. This work is expected to expand the utility of 2D antimonene (AM) to biomedical applications through the development of an entirely novel PTA platform.
Keyphrases
- climate change
- cancer therapy
- drug delivery
- quantum dots
- drug release
- photodynamic therapy
- human health
- sensitive detection
- high glucose
- diabetic rats
- fluorescence imaging
- machine learning
- drug induced
- high throughput
- fluorescent probe
- energy transfer
- gold nanoparticles
- reduced graphene oxide
- risk assessment
- single cell
- ionic liquid
- transition metal
- highly efficient
- heavy metals