Acute kidney transplant rejection mediated by angiotensin II type 1 receptor antibodies in a pediatric hyperimmune patient.
Isabella GuzzoFederica MorolliFrancesca Diomedi CamasseiAntonina PiazzaElvira PoggiLuca Dello StrologoPublished in: Pediatric nephrology (Berlin, Germany) (2016)
Testing for AT1R-Ab in any hypertensive patient with acute rejection who tests negative or weakly positive for C4d and negative for HLA-DSA and who is refractory to therapy is highly advisable. Pre-transplant AT1R-Ab may be indicative of the outcome in patients whose first transplant failed. Prompt initiation of treatment with losartan-immediately after transplantation in patients with pre-existing AT1R-Ab-should be encouraged.
Keyphrases
- angiotensin ii
- liver failure
- end stage renal disease
- angiotensin converting enzyme
- vascular smooth muscle cells
- respiratory failure
- case report
- ejection fraction
- newly diagnosed
- chronic kidney disease
- drug induced
- peritoneal dialysis
- prognostic factors
- aortic dissection
- cell therapy
- hepatitis b virus
- patient reported outcomes
- mesenchymal stem cells
- patient reported
- acute respiratory distress syndrome
- smoking cessation
- childhood cancer