Population pharmacokinetics, safety and dosing optimization of voriconazole in patients with liver dysfunction: A prospective observational study.
Dan TangMiao YanBai-Li SongYi-Chang ZhaoYi-Wen XiaoFeng WangWu LiangBi-Kui ZhangXi-Jing ChenJian-Jun ZouYi TianWen-Long WangYong-Fang JiangGuo-Zhong GongMin ZhangDa-Xiong XiangPublished in: British journal of clinical pharmacology (2020)
Lower doses and longer dosing intervals should be considered for patients with liver dysfunction. TBIL-based dosing regimens provide a practical strategy for achieving voriconazole therapeutic range and therefore maximizing treatment outcomes.
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