Perivenous Stellate Cells Are the Main Source of Myofibroblasts and Cancer-Associated Fibroblasts Formed After Chronic Liver Injuries.
Shan-Shan WangXinyu Thomas TangMinghui LinJia YuanYi Jacky PengXiujuan YinGuoGuo ShangGaoxiang GeZhenggang RenBo O ZhouPublished in: Hepatology (Baltimore, Md.) (2022)
In conclusion, Tcf21-CreER-targeted perivenous stellate cells are the main source of myofibroblasts and CAFs in chronically injured livers. TGF-β signaling links HSC activation to liver fibrosis and tumorigenesis.