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Perivenous Stellate Cells Are the Main Source of Myofibroblasts and Cancer-Associated Fibroblasts Formed After Chronic Liver Injuries.

Shan-Shan WangXinyu Thomas TangMinghui LinJia YuanYi Jacky PengXiujuan YinGuoGuo ShangGaoxiang GeZhenggang RenBo O Zhou
Published in: Hepatology (Baltimore, Md.) (2022)
In conclusion, Tcf21-CreER-targeted perivenous stellate cells are the main source of myofibroblasts and CAFs in chronically injured livers. TGF-β signaling links HSC activation to liver fibrosis and tumorigenesis.
Keyphrases
  • induced apoptosis
  • liver fibrosis
  • cell cycle arrest
  • endoplasmic reticulum stress
  • oxidative stress
  • signaling pathway
  • cell death
  • cancer therapy
  • transforming growth factor
  • drug delivery
  • extracellular matrix