The effect of full dose composite tissue allotransplantation immunosuppression on allograft motor nerve regeneration in a rat sciatic nerve model.

Jong Pil KimCaroline A HundepoolPatricia F FriedrichSteven L MoranAllen T BishopAlexander Y Shin

Published in: Microsurgery (2017)

FK506 significantly enhanced motor recovery after allograft reconstruction. This effect was comparable between combination treatment (low-dose FK506 and MMF) and triple therapy (high-dose FK506 and MMF plus prednisolone). However, triple therapy was more effective in suppressing skin rejection.

Keyphrases

high dose
low dose
stem cells
wound healing
signaling pathway
oxidative stress
kidney transplantation
soft tissue
replacement therapy