Protective effects of intracerebroventricular adiponectin against olfactory impairments in an amyloid β1-42 rat model.

Mara A Guzmán-RuizAmor Herrera-GonzálezAdriana JiménezAlan Candelas-JuárezCrystal Quiroga-LozanoClaudia Castillo-DíazErika Orta-SalazarDiana Organista-JuárezSofía Díaz-CintraRosalinda Guevara-Guzmán

Published in: BMC neuroscience (2021)

The present study describes the olfactory impairment of Aβ treated rats and evidences the protective role that APN plays in the brain, by preventing the olfactory impairment induced by Aβ1-42. These results may lead to APN-based pharmacological therapies aimed to ameliorate AD neurotoxic effects.

Keyphrases

metabolic syndrome
resting state
insulin resistance
multiple sclerosis
functional connectivity