The acute blood pressure-lowering effect of amiloride is independent of endothelial ENaC and eNOS in humans and mice.

Rikke YdegaardHenrik AndersenChristina S OxlundIb A JacobsenPernille B L HansenJonathan F JürgensenAntonio Augusto PelusoPaul M VanhoutteMette StaehrPer SvenningsenBoye L Jensen

Published in: Acta physiologica (Oxford, England) (2018)

Amiloride has an acute hypotensive action not dependent on ENaC and eNOS and likely related to the heart.

Keyphrases

liver failure
endothelial cells
blood pressure
respiratory failure
drug induced
nitric oxide synthase
pi k akt
aortic dissection
heart failure
hepatitis b virus
heart rate
atrial fibrillation
type diabetes
extracorporeal membrane oxygenation
skeletal muscle
mechanical ventilation