Glycolysis: An early marker for vancomycin-specific T-cell activation.
Joshua GardnerSean HammondRebecca L JensenAndrew GibsonMatthew S KrantzMichael Ardern-JonesElizabeth J PhillipsMunir PirmohamedAmy E ChadwickCatherine BettsDean J NaisbittPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2024)
These studies describe the glycolytic shift of CD4+ and CD8+ T cells following vancomycin exposure. Since similar glycolytic switching is observed with teicoplanin, which did not activate T cells, it is possible the master switch for T-cell activation is located upstream of metabolic signalling.