Potential role for nectin-4 in the pathogenesis of pre-eclampsia: a molecular genetic study.

Mayuko ItoHaruki NishizawaMakiko TsutsumiAsuka KatoYoshiko SakabeYoshiteru NodaAkiko OhwakiJun MiyazakiTakema KatoKazuya ShiogamaTakao SekiyaHiroki KurahashiTakuma Fujii

Published in: BMC medical genetics (2018)

There are as yet unknown factors that induce nectin-4 overexpression in trophoblast cells that may contribute to abnormal placentation via an aberrant immune response and the onset of a pre-eclamptic pregnancy.

Keyphrases

immune response
induced apoptosis
cell cycle arrest
cell proliferation
preterm birth
dendritic cells
transcription factor
toll like receptor
endoplasmic reticulum stress
oxidative stress
copy number
pregnancy outcomes
inflammatory response
dna methylation