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XPO1 inhibitors represent a novel therapeutic option in Adult T-cell Leukemia, triggering p53-mediated caspase-dependent apoptosis.

Eline BoonsTatiane C NogueiraTim DierckxSoraya Maria MenezesMaarten JacquemynSharon TamirYosef LandesmanLourdes FarréAchiléa BittencourtKeisuke KataokaSeishi OgawaRobert SnoeckGraciela AndreiJohan Van WeyenberghDirk Daelemans
Published in: Blood cancer journal (2021)
Keyphrases
  • cell death
  • cell cycle arrest
  • endoplasmic reticulum stress
  • induced apoptosis
  • oxidative stress
  • acute myeloid leukemia
  • bone marrow
  • childhood cancer