2-Phenyl-3-(phenylselanyl)benzofuran elicits acute antidepressant-like action in male Swiss mice mediated by modulation of the dopaminergic system and reveals therapeutic efficacy in both sexes.
Taís da Silva Teixeira RechAmália Gonçalves AlvesDianer Nornberg StrelowLetícia Devantier KrügerLuiz Roberto Carraro JúniorJosé Sebastião Dos Santos NetoAntonio Luiz BragaCesar Augusto BrüningCristiani Folharini BortolattoPublished in: Psychopharmacology (2021)
Our findings provide evidence of the involvement of the dopaminergic system in the acutely antidepressant-like action of SeBZF1 in male mice and reveal the compound efficacy when acute or repeatedly administered in both sexes.