Radiosynthesis and in Vivo Evaluation of [11C]MPC-6827, the First Brain Penetrant Microtubule PET Ligand.
J S Dileep KumarKiran Kumar Solingapuram SaiJaya PrabhakaranHakeem R OufkirGayathri RamanathanChristopher T WhitlowHima DileepAkiva MintzJ John MannPublished in: Journal of medicinal chemistry (2018)
Abnormalities of microtubules (MTs) are implicated in the pathogenesis of many CNS diseases. Despite the potential of an MT imaging agents, no PET ligand is currently available for in vivo imaging of MTs in the brain. We radiolabeled [11C]MPC-6827, a high affinity MTA, and demonstrated its specific binding in rat and mice brain using PET imaging. Our experiments show that [11C]MPC-6827 has specific binding to MT in brain, and it is the first MT-binding PET ligand.
Keyphrases
- pet imaging
- resting state
- white matter
- positron emission tomography
- computed tomography
- high resolution
- pet ct
- functional connectivity
- cerebral ischemia
- multiple sclerosis
- adipose tissue
- mass spectrometry
- risk assessment
- climate change
- binding protein
- photodynamic therapy
- transcription factor
- high fat diet induced
- skeletal muscle