Gene flow analysis method, the D-statistic, is robust in a wide parameter space.
Yichen ZhengAxel JankePublished in: BMC bioinformatics (2018)
The D-statistic, as a method to detect gene flow, is robust against a wide range of genetic distances (divergence times) but it is sensitive to population size. The D-statistic should only be applied with critical reservation to taxa where population sizes are large relative to branch lengths in generations.