The protein phosphatase PP6 promotes RIPK1-dependent PANoptosis.

Ratnakar R BynigeriR K Subbarao MalireddiRaghvendra MallJon P ConnellyShondra M Pruett-MillerThirumala-Devi Kanneganti

Published in: BMC biology (2024)

Overall, our findings demonstrate a key requirement for the phosphatase PP6 complex in the activation of TAK1i-induced, RIPK1-dependent PANoptosis, suggesting this complex could be therapeutically targeted in inflammatory conditions.

Keyphrases

oxidative stress
diabetic rats
high glucose
protein kinase
cancer therapy
drug induced
amino acid
drug delivery