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The protein phosphatase PP6 promotes RIPK1-dependent PANoptosis.

Ratnakar R BynigeriR K Subbarao MalireddiRaghvendra MallJon P ConnellyShondra M Pruett-MillerThirumala-Devi Kanneganti
Published in: BMC biology (2024)
Overall, our findings demonstrate a key requirement for the phosphatase PP6 complex in the activation of TAK1i-induced, RIPK1-dependent PANoptosis, suggesting this complex could be therapeutically targeted in inflammatory conditions.
Keyphrases
  • oxidative stress
  • diabetic rats
  • high glucose
  • protein kinase
  • cancer therapy
  • drug induced
  • amino acid
  • drug delivery