Roflupram exerts neuroprotection via activation of CREB/PGC-1α signalling in experimental models of Parkinson's disease.

Jiahong ZhongWenli DongYunyun QinJinfeng XieJiao XiaoJiangping XuHai-Tao Wang

Published in: British journal of pharmacology (2020)

Roflupram protected dopaminergic neurons from apoptosis via the CREB/PGC-1α pathway in PD models. Hence, roflupram has potential as a protective drug in the treatment of PD.

Keyphrases

skeletal muscle
oxidative stress
spinal cord
cell death
brain injury
combination therapy
human health
spinal cord injury
risk assessment
cerebral ischemia
adverse drug
cell proliferation
drug induced