Development of caspase-3-selective activity-based probes for PET imaging of apoptosis.

Louis LauwerysLucas BeroskeAngelo SolaniaChristel VangestelAlan MirandaNele Van GielKaruna AdhikariAnne-Marie LambeirLeonie WyffelsDennis WolanPieter Van der VekenFilipe Elvas

Published in: EJNMMI radiopharmacy and chemistry (2024)

F]MICA-316, showed an increase uptake in an in vitro apoptosis model and was able to selectively bind caspase-3 in apoptotic tumour cells. In order to distinguish therapy-responsive from non-responsive tumours, the next generation of caspase-3-selective ABPs will be developed with higher tumour accumulation and in vivo stability.

Keyphrases

cell death
cell cycle arrest
induced apoptosis
pet imaging
endoplasmic reticulum stress
oxidative stress
cancer therapy
small molecule
single molecule
pet ct
nucleic acid