Adjuvant Systemic Therapy after Chemoradiation and Brachytherapy for Locally Advanced Cervical Cancer: A Systematic Review and Meta-Analysis.
Nanda HorewegPrachi MittalPatrycja L GradowskaIngrid A BoereSupriya ChopraRemi A NoutPublished in: Cancers (2021)
The addition of adjuvant platinum-pyrimidine antagonist or platinum-taxane after chemoradiation and brachytherapy does not significantly improve overall survival, while acute toxicity is significantly increased. These adjuvant treatment strategies can therefore not be recommended for unselected patients with locally advanced cervical cancer.
Keyphrases
- locally advanced
- rectal cancer
- neoadjuvant chemotherapy
- early stage
- squamous cell carcinoma
- radiation therapy
- phase ii study
- high dose
- liver failure
- oxidative stress
- drug induced
- respiratory failure
- clinical trial
- intensive care unit
- mesenchymal stem cells
- hepatitis b virus
- metastatic breast cancer
- low dose
- extracorporeal membrane oxygenation