Inhibition of the NADPH Oxidase Pathway Reduces Ferroptosis during Septic Renal Injury in Diabetic Mice.

Weifeng YaoHaofeng LiaoMengya PangLijie PanYu GuanXiaolei HuangZiqing HeiChenfang LuoMian Ge

Published in: Oxidative medicine and cellular longevity (2022)

These results suggest that targeting NADPH-mediated ROS release and ferroptosis accumulation is a novel therapeutic strategy to protect the kidney from septic injury in patients with obesity and type 2 DM.

Keyphrases

cell death
acute kidney injury
reactive oxygen species
metabolic syndrome
insulin resistance
weight loss
type diabetes
dna damage
weight gain
high fat diet induced
oxidative stress
drug delivery
glycemic control
skeletal muscle