Dyrk1a Phosphorylation of α -Synuclein Mediating Apoptosis of Dopaminergic Neurons in Parkinson's Disease.

Yuxuan Yong Qinfen Wu Xinling Meng Ranran Lu Huan Xia Feifei Pei Xin-Ling Yang

Published in: Parkinson's disease (2023)

-synuclein phosphorylation modifications, and dyrk1a knockdown activates the PI3K/AKT pathway and reduces dopaminergic neuron apoptosis. It provides a theoretical basis for the group to further investigate the molecular mechanism.

Keyphrases

oxidative stress
endoplasmic reticulum stress
cell cycle arrest
cell death
protein kinase
spinal cord