Circular RNA as biomarkers for acute ischemic stroke: A systematic review and meta-analysis.

Xiao ZhangMengyao WanXiaoli MinGuanglei ChuYu-Min LuoZiping HanWei LiRan XuJichang LuoWenjing LiYutong YangYan MaLingyun JiaTao Wang

Published in: CNS neuroscience & therapeutics (2023)

This study demonstrates that circRNAs (circRNA HECTD1, circRNA DLGAP4, circRNA CDC14A, circRNA SCMH1, and circRNA TLK1) generally are promising as potential biomarkers for AIS. However, due to the limited number of studies, diagnostic value of individual circRNA could not be validated. More in vitro and in vivo functional studies are needed.

Keyphrases

acute ischemic stroke
cell cycle
case control
cell proliferation