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B cell-rich non-neoplastic sentinel lesion preceding primary central nervous system lymphoma.

Rodrigo JavierNawal ShaikhMaciej S LesniakAdam SonabendRoger StuppAmir BehdadCraig M Horbinski
Published in: Diagnostic pathology (2018)
Primary central nervous system lymphoma (PCNSL) is an uncommon tumor in the brain. Although most PCNSL are readily diagnosed as diffuse large B cell lymphoma (DLBCL) on the first biopsy, very rare cases have been described in which the first detected intracerebral lesions are non-neoplastic, and are composed mostly of perivascular T cells, not B cells. This phenomenon is known as "sentinel lesions."
Keyphrases
  • diffuse large b cell lymphoma
  • epstein barr virus
  • cerebrospinal fluid
  • white matter
  • resting state
  • multiple sclerosis
  • functional connectivity
  • cerebral ischemia
  • brain injury
  • subarachnoid hemorrhage