Glial fibrillary acidic protein for the early diagnosis of intracerebral hemorrhage: Systematic review and meta-analysis of diagnostic test accuracy.

Luke A PerryTom LucarelliJahan C Penny-DimriMatthew Df McInnesStefania MondelloAlejandro BustamanteJoan MontanerChristian FoerchPatrick KwanStephen DavisBernard Yan

Published in: International journal of stroke : official journal of the International Stroke Society (2018)

GFAP is a promising diagnostic biomarker for ICH diagnosis in the early pre-hospital phase. Test accuracy is affected by assay subtype, but there are still unexplained sources of heterogeneity. High quality, international multi-center trials are warranted to develop and validate a point-of-care GFAP assay for the rapid triage and evaluation of acute stroke in the pre-hospital setting.

Keyphrases

systematic review
high throughput
healthcare
emergency department
acute care
meta analyses
brain injury
adverse drug
single cell
drinking water
neuropathic pain
ionic liquid
spinal cord
spinal cord injury
binding protein
amino acid
protein protein
loop mediated isothermal amplification