SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines.

Giovanni SalvatoriLaura LubertoMariano MaffeiLuigi AurisicchioGiuseppe RoscilliFabio PalomboEmanuele Marra

Published in: Journal of translational medicine (2020)

COVID-19 has rapidly spread all over the world, progressing into a pandemic. This situation has urgently impelled many companies and public research institutes to concentrate their efforts on research for effective therapeutics. Here, we outline the strategies and targets currently adopted in developing a vaccine against SARS-CoV-2. Based on previous evidence and experience with SARS and MERS, the primary focus has been the Spike protein, considered as the ideal target for COVID-19 immunotherapies.

Keyphrases

sars cov
respiratory syndrome coronavirus
coronavirus disease
protein protein
healthcare
small molecule
binding protein