Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain.
Nagendran MuthusamyAndrew BrummXuying ZhangS Thomas CarmichaelH Troy GhashghaeiPublished in: Scientific reports (2018)
The stem cell source of neural and glial progenitors in the periventricular regions of the adult forebrain has remained uncertain and controversial. Using a cell specific genetic approach we rule out Foxj1+ ependymal cells as stem cells participating in neurogenesis and gliogenesis in response to acute injury or stroke in the mouse forebrain. Non stem- and progenitor-like responses of Foxj1+ ependymal cells to injury and stroke remain to be defined and investigated.
Keyphrases
- aortic dissection
- stem cells
- induced apoptosis
- cell cycle arrest
- atrial fibrillation
- endoplasmic reticulum stress
- gene expression
- signaling pathway
- genome wide
- mass spectrometry
- dna methylation
- cell therapy
- young adults
- brain injury
- hepatitis b virus
- high resolution
- atomic force microscopy
- cerebral ischemia
- high speed