Copper-catalyzed oxidative intermolecular 1,2-alkylarylation of styrenes with ethers and indoles.

A new copper-catalyzed oxidative three-component intermolecular 1,2-alkylarylation of styrenes with ethers and indoles is disclosed. This method utilizes TBPB as an oxidant to efficiently construct C(sp3)-C(sp3) and C(sp3)-C(sp2) bonds in one step through probable radical and electrophilic alkylation processes, respectively, and a variety of functional groups are well tolerated.