Assessment of prenatal cerebral and cardiac metabolic changes in a rabbit model of fetal growth restriction based on 13C-labelled substrate infusions and ex vivo multinuclear HRMAS.
Rui Vasco SimoesMiquel E CabañasCarla LoreiroMiriam IllaFatima CrispiEduard GratacósPublished in: PloS one (2018)
Our results indicate specific functional changes in cerebral and cardiac metabolism of FGR fetuses under nutrient infusion, suggesting glial impairment and restricted mitochondrial metabolism concomitant with slower cell membrane turnover in cardiomyocytes, respectively. These prenatal metabolic changes underlie neurodevelopmental and cardiovascular problems observed in this FGR model and in clinical patients, paving the way for future studies aimed at evaluating metabolic function postnatally and in response to stress and/or treatment.
Keyphrases
- end stage renal disease
- pregnant women
- subarachnoid hemorrhage
- newly diagnosed
- left ventricular
- chronic kidney disease
- ejection fraction
- mental health
- oxidative stress
- low dose
- prognostic factors
- heart failure
- patient reported outcomes
- neuropathic pain
- endothelial cells
- body composition
- replacement therapy
- stress induced
- amino acid
- structural basis
- case control