Ulapualides C-E Isolated from a Hawaiian Hexabranchus sanguineus Egg Mass.
Stephen M ParrishWesley YoshidaBaojun YangPhilip G WilliamsPublished in: Journal of natural products (2017)
Three new ulapualides (3-5) were isolated from egg masses of the nudibranch Hexabranchus sanguineus. The structures of 3-5 were deduced by analyses of physical and spectroscopic data in comparisons with ulapualides A (1) and B (2). Ulapualide C demonstrated submicromolar cytotoxicity against select NCI cell lines (768-0, DU-145, MDA-MB-231, and A549) with the most potent activity against MDA-MB-231 cells (IC50 0.58 μM). Ulapualides A (1) and B (2) were 2- to 4-fold more potent than 3.
Keyphrases
- cell cycle arrest
- cell death
- breast cancer cells
- induced apoptosis
- pi k akt
- anti inflammatory
- molecular docking
- physical activity
- mental health
- electronic health record
- signaling pathway
- high resolution
- endoplasmic reticulum stress
- big data
- magnetic resonance imaging
- computed tomography
- machine learning
- oxidative stress
- magnetic resonance
- cell proliferation
- deep learning
- data analysis